LIG-Based High-Sensitivity Multiplexed Sensing System for Simultaneous Monitoring of Metabolites and Electrolytes

Area of Science:

• Biomedical Engineering
• Materials Science
• Analytical Chemistry

Background:

• Growing interest in continuous body monitoring via wearable biosensors.
• Advancements in medical environments and smartphone integration drive demand for non-invasive monitoring solutions.

Purpose of the Study:

• To develop a wearable multiplexed bio-sensing system for non-invasive monitoring of key analytes and temperature.
• To integrate the system with a smartphone application for seamless data access and analysis.

Main Methods:

• Development of laser-induced graphene (LIG)-based sensors for glucose, lactate, sodium (Na+), potassium (K+), and temperature.
• Utilized potentiometric and amperometric measurement techniques with integrated calibration.
• Incorporated a microcontroller unit (MCU) for signal processing and wireless communication.

Main Results:

• LIG electrodes exhibited a 16-fold increase in active surface area, enhancing sensor performance.
• High sensitivity and low detection limits were achieved for glucose and lactate sensors.
• Accurate potentiometric sensing of Na+ and K+ concentrations and precise temperature monitoring within the physiological range.

Conclusions:

• The developed wearable biosensing system offers a fast, cost-effective, and non-invasive approach for continuous health monitoring.
• The LIG-based sensors demonstrate significant potential for improving personalized healthcare through smartphone-integrated diagnostics.
• This technology paves the way for advanced remote patient monitoring and proactive health management.