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Modeling and Evaluation of Penetration Process Based on 3D Mechanical Simulation.

Xiaohan Chen¹, Huiying Gong¹, Bin Yang¹

¹National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Engineering Research Center of Trusted Behavior Intelligence, Ministry of Education, Tianjin Key Laboratory of Intelligent Robotics, Institute of Robotics and Automatic Information System, Nankai University, Tianjin 300350, China.

Sensors (Basel, Switzerland)

|November 9, 2024

Summary

This study models cell penetration during micromanipulation to minimize cell deformation and damage. Findings help optimize procedures for safer and more efficient cell injection and enucleation.

Keywords:

cell penetration finite element simulation force and deformation intracellular stress micromanipulation

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Area of Science:

Biomedical Engineering
Cell Biology
Biophysics

Background:

Cell penetration is crucial for micromanipulation procedures like cell injection.
Significant cell deformation during penetration can cause damage, impacting experimental outcomes.
Reducing mechanical stress on cells is vital for maintaining viability.

Purpose of the Study:

To model and evaluate the cell penetration process in biological micromanipulation.
To identify key parameters influencing cell deformation and stress.
To reduce cell damage during micromanipulation procedures.

Main Methods:

Development of a finite element model (FEM) to simulate cell penetration.
Verification of the FEM through comparison with experimental cell deformation data.
Analysis of mechanical responses by varying micropipette geometry, cell properties, and penetration depth.

Main Results:

Quantification of cell deformation and intracellular stress during penetration.
Identification of relationships between operational parameters and cell mechanical responses.
Establishment of a correlation between intracellular stress and cell penetration depth.

Conclusions:

The developed FEM accurately simulates cell penetration, aiding in understanding mechanical stress.
Optimized operation plans can be derived from the evaluation results.
Enhanced efficiency and safety of cell penetration procedures are achievable.