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Atomic Force Microscopy

Atomic Force Microscopy

Atomic force microscopy (AFM) is a type of scanning probe microscopy that can analyze topographic details of various specimens like ceramics, glass, polymers, and biological samples. AFM offers over 1000 times more resolution than the optical imaging system. Images generated from AFM are three-dimensional surface profiles, offering an advantage over the flat, two-dimensional images from other imaging techniques.
The AFM Probe
The probe is regarded as the heart of any AFM setup and comprises the...

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Related Experiment Video

Updated: Jan 18, 2026

AFM and Microrheology in the Zebrafish Embryo Yolk Cell

AFM and Microrheology in the Zebrafish Embryo Yolk Cell

Published on: November 29, 2017

Modeling and Validation of Oocyte Mechanical Behavior Using AFM Measurement and Multiphysics Simulation.

Yue Du¹, Yu Cai^2,3, Zhanli Yang^2,3

¹School of Computer and Information Science, Qinghai Institute of Technology, Xining 810016, China.

Sensors (Basel, Switzerland)

|September 13, 2025

Summary

This summary is machine-generated.

This study developed mechanical models to simulate oocyte deformation, revealing distinct properties of the zona pellucida (ZP) and cytoplasm. These models enhance oocyte quality assessment and cell mechanics research.

Keywords:

AFM cell mechanical model creep behavior layered structure three-phase flow model viscoelastic properties

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Last Updated: Jan 18, 2026

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Author Spotlight: Elucidating the Dynamics of Mechano-Transduction and Nuclear Agitation in Mouse Oocytes

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Published on: January 12, 2024

Area of Science:

Biophysics
Cell Mechanics
Finite Element Analysis

Background:

Oocyte mechanical properties are crucial for quality assessment.
Simulating oocyte deformation requires distinct models for cell-tool and cell-fluid interactions.
Understanding intracellular mechanical responses provides insights into oocyte viability.

Purpose of the Study:

To develop and validate mechanical models for simulating porcine oocyte deformation under various conditions.
To investigate the mechanical properties of the zona pellucida (ZP) and cytoplasm.
To establish a foundation for improved oocyte quality assessment.

Main Methods:

Developed a layered finite element (FE) model incorporating viscoelastic properties of ZP and cytoplasm.
Utilized Atomic Force Microscopy (AFM) to measure Young's modulus and creep behavior.
Employed a three-phase flow model to simulate oocyte-fluid interactions in microfluidic channels.

Main Results:

Determined Young's modulus for ZP (7 kPa) and cytoplasm (1.55 kPa).
Achieved high accuracy (5.2% error) in simulating oocyte deformation through micropipettes using the FE model.
Validated the three-phase flow model's efficacy in simulating oocyte deformation in microfluidic channels.

Conclusions:

The developed mechanical models accurately predict oocyte deformation during micromanipulation and fluid flow.
Mechanical characterization of oocyte subcomponents is essential for accurate modeling.
This research offers a valuable tool for oocyte quality assessment and cell mechanics studies.