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Fetal Cortical Abnormalities Identified on Ultrasound.

Mara Rosner1, Casey Reed1, Aylin Tekes2

  • 1Department of Gynecology and Obstetrics, Center for Fetal Therapy, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Diagnostics (Basel, Switzerland)
|November 9, 2024
PubMed
Summary

Prenatal ultrasound can detect fetal cortical abnormalities during mid-trimester scans. Early diagnosis of neuronal migration issues aids in clinical counseling and understanding potential developmental impacts.

Keywords:
ciliopathycortical dysplasianeuronal migrationneurosonogram

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Medical Imaging

Background:

  • Neuronal cell differentiation and migration are crucial for fetal brain development.
  • These processes peak around 20-22 weeks gestation, coinciding with routine anatomic surveys.
  • Abnormalities in cortical migration can indicate genetic issues or fetal injury, impacting development.

Purpose of the Study:

  • To highlight the utility of prenatal ultrasound in diagnosing fetal cortical abnormalities.
  • To present cases where mid-trimester ultrasound enabled prompt diagnosis and guided counseling.
  • To emphasize the importance of recognizing cortical migration abnormalities during fetal development.

Main Methods:

  • Case series describing three patients with fetal cortical abnormalities.
  • Utilized prenatal ultrasound imaging for diagnosis during the mid-trimester.
  • Correlated imaging findings with clinical presentation and counseling.

Main Results:

  • Prenatal ultrasound imaging was instrumental in diagnosing fetal cortical abnormalities.
  • Diagnoses were made promptly in the mid-trimester.
  • Imaging facilitated effective clinical counseling for the identified cases.

Conclusions:

  • Mid-trimester prenatal ultrasound is a valuable tool for detecting fetal cortical abnormalities.
  • Early diagnosis of neuronal migration disorders impacts clinical management and counseling.
  • Recognizing these abnormalities aids in predicting and managing potential neurodevelopmental outcomes.