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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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Mediterranean Diet Pattern: Potential Impact on the Different Altered Pathways Related to Cardiovascular Risk in
Jordi Rovira1,2, María José Ramirez-Bajo1,2, Elisenda Bañon-Maneus1,2
1Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Institut d'Investigacions Biomètiques August Pi i Sunyer (IDIBAPS), 08027 Barcelona, Spain.
Nutrients
|November 9, 2024
Summary
Cardiovascular disease (CVD) in chronic kidney disease (CKD) is linked to altered serum metabolites and proteins. The Mediterranean diet may help prevent CVD in CKD patients by targeting these pathways.
Area of Science:
- Biochemistry
- Proteomics
- Metabolomics
Background:
- Cardiovascular disease (CVD) is the leading cause of mortality in patients with chronic kidney disease (CKD).
- The Mediterranean diet shows potential in reducing CVD risk through improved endothelial function, inflammation, lipid profile, and blood pressure.
- Integrating metabolomic and proteomic analyses can elucidate uremia-induced CVD pathways in CKD, identifying those modifiable by diet.
Purpose of the Study:
- To investigate the serum metabolomic and proteomic profiles in advanced chronic kidney disease (aCKD).
- To identify specific pathways and biomarkers associated with CVD risk in aCKD patients.
- To explore potential dietary interventions, like the Mediterranean diet, for CVD prevention in CKD.
Main Methods:
- Serum samples from 19 aCKD patients and 27 healthy volunteers underwent metabolomic and proteomic analysis.
- Metabolites were quantified using four distinct methods; proteins were analyzed after depleting seven abundant serum proteins.
- Integrative analysis utilized MetaboAnalyst 4.0 and STRING 11.0 for pathway and biomarker identification.
Main Results:
- 135 metabolites and 75 proteins were differentially expressed in aCKD patients compared to controls.
- Pathway analysis revealed significant alterations in innate immune system pathways (complement, coagulation, neutrophil degranulation) and disrupted linoleic acid and cholesterol metabolism.
- Key altered metabolites and proteins included glutathione peroxidase 3, carnitine, homocitrulline, 3-methylhistidine, and various amino acids.
Conclusions:
- Significant dysregulation of serum metabolome and proteome exists in aCKD, linked to endothelial dysfunction and CVD pathways.
- These findings highlight potential therapeutic targets for CVD in CKD.
- Dietary interventions, such as the Mediterranean diet, may offer a beneficial strategy for CVD prevention in CKD patients.
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