[Inhibiting effect of dioxidine on corticosteroid secretion in an experiment]

The determination of corticosterone and aldosterone levels in the peripheral blood of rats and a cortisol level in the blood of guinea pigs by a radioimmunoassay following the administration of dioxydin (1,4-N-oxide 2 2,3-dioxymethylquinoxaline) has shown that it produces an inhibiting effect upon the secretion of corticosteroid hormones in animals with a diverse direction of their biosynthesis. There is a dose dependence of the effect detected. Substitution therapy with corticosteroids cuts short adrenal insufficiency caused by dioxydin.