Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fluoride absorption: independence from plasma fluoride levels.

G M Whitford, J L Williams

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
    |April 1, 1986
    PubMed
    Summary

    Plasma fluoride levels do not appear to regulate fluoride absorption in rats. This study found no evidence of homeostatic regulation of fluoride concentrations, even with varying intake levels.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Fluoride and Oral Health.

    Community dental health·2016
    Same author

    Validation of fingernail fluoride concentration as a predictor of risk for dental fluorosis.

    Caries research·2012
    Same author

    An assessment of bone fluoride and osteosarcoma.

    Journal of dental research·2011
    Same author

    Assessment of dental fluorosis in Mmp20 +/- mice.

    Journal of dental research·2011
    Same author

    Development of gold standard ion-selective electrode-based methods for fluoride analysis.

    Caries research·2010
    Same author

    Skeletal fluorosis due to excessive tea and toothpaste consumption.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2010

    Area of Science:

    • Physiology
    • Toxicology
    • Biochemistry

    Background:

    • Previous research suggested plasma fluoride levels homeostatically regulate fluoride absorption.
    • This proposed inverse relationship in rats was questioned due to experimental design limitations.

    Purpose of the Study:

    • To investigate the influence of plasma fluoride concentrations on fluoride absorption in rats.
    • To determine if plasma fluoride levels are homeostatically regulated.

    Main Methods:

    • Evaluated urinary fluoride excretion percentage.
    • Measured fluoride concentration in femur epiphyses.
    • Analyzed plasma fluoride concentration curves after oral doses.
    • Assessed residual gastrointestinal fluoride amounts.

    Related Experiment Videos

    Main Results:

    • No tested method indicated that plasma fluoride levels affect the rate or extent of fluoride absorption.
    • Urinary excretion, bone fluoride, plasma concentration curves, and GI tract residuals showed no correlation with plasma fluoride levels.

    Conclusions:

    • Fluoride absorption appears independent of plasma fluoride levels in rats, except possibly at pharmacologic or toxic doses.
    • The findings challenge the concept of homeostatic regulation of plasma fluoride concentrations.