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Self-healing adhesive hydrogels for sustained ozone release: Enhanced antibacterial properties and improved wound
Shanbo Ma1, Conghui Han2, Xi Chen2
1Department of Pharmacy, Xijing Hospital, Air Force Medical University, Xi'an 710032, PR China.
Abstract:
Antibacterial hydrogels have generated significant interest for their potential therapeutic applications. Ozone (O₃) is recognized for its antibacterial, anti-inflammatory, immunomodulatory, and anti-hypoxic properties, along with its minimal residual impact. However, the development of sustained O₃-release antibacterial hydrogels has been challenging due to the low solubility and short lifespan of ozone. We present an ozone-loaded emulsion hydrogel (ozonegel), which encapsulates ozonized oil within a nanoclay-poly(methacryloxyethyl sulfobetaine) supramolecular network. This adhesive, self-healing ozonegel achieves high ozone loading (91.3 mmol/kg) and releases O₃ and reactive oxygen species (ROS) over 36 h. It demonstrates broad antibacterial and anti-inflammatory effects, promoting wound healing. The remarkable properties of ozonegels suggest significant potential for advanced biomedical applications.
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