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Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Published on: November 27, 2019
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Hepatitis E as a trigger for acute-on-chronic liver failure.
Maria Buti1,2,3, Juan Carlos Ruiz-Cobo1,2, Rafael Esteban1
1Liver Unit, Internal Medicine Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
Clinical and Molecular Hepatology
|November 11, 2024
Summary
Hepatitis E virus (HEV) infection can cause severe liver issues in those with cirrhosis. Early diagnosis and HEV vaccination are key to preventing serious outcomes like acute-on-chronic liver failure.
Area of Science:
- Hepatology
- Virology
- Public Health
Background:
- Acute hepatitis E virus (HEV) infection is usually self-limiting.
- Patients with chronic liver disease are at risk for severe HEV manifestations, including acute-on-chronic liver failure (ACLF).
- Hepatitis A, E, and B are significant causes of ACLF.
Purpose of the Study:
- To highlight the risks of HEV in patients with cirrhosis.
- To emphasize the importance of early HEV diagnosis in ACLF patients.
- To advocate for preventive measures against HEV.
Main Methods:
- Literature review on HEV infection and ACLF.
- Analysis of HEV's role in liver disease progression.
- Discussion of diagnostic and preventive strategies.
Main Results:
- HEV can lead to severe outcomes in individuals with pre-existing liver disease.
- Early screening and diagnosis of HEV in cirrhotic patients with ACLF are crucial.
- Antiviral therapy and vaccination are potential management tools.
Conclusions:
- Active screening for HEV in high-risk populations improves patient management.
- Timely diagnosis and treatment can mitigate HEV-related morbidity and mortality.
- HEV vaccination is recommended for vulnerable groups to reduce disease burden.
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