Precision Cancer Therapy Enabled Anti-Epidermal Growth Factor Receptor-Conjugated Manganese Core Phthalocyanine...

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Oncology

Background:

• Cancer poses a significant global health challenge, necessitating advanced treatments with reduced side effects.
• Targeted photothermal/photodynamic therapy (PTT/PDT) using functional nanomaterials offers a promising approach for precise cancer diagnosis and treatment.
• Developing innovative biomaterials is crucial for synergistic cancer therapy and real-time monitoring.

Purpose of the Study:

• To synthesize and evaluate a novel anti-EGFR-MPB composite biomaterial for targeted breast cancer imaging and treatment.
• To investigate the dual-imaging capabilities and therapeutic efficacy of the biomaterial in preclinical cancer models.
• To optimize the photothermal/photodynamic therapy parameters for triple-negative breast cancer treatment.

Main Methods:

• Solvothermal synthesis of anti-EGFR-MPB nanocomposite.
• In vitro and in vivo evaluation in breast cancer mouse models.
• Dual-mode imaging (fluorescence and photoacoustic imaging - PAI) for real-time monitoring.
• Assessment of therapeutic efficacy via laser irradiation and biological/histological analyses.

Main Results:

• The anti-EGFR-MPB nanocomposite demonstrated precise targeting of cancer cells and effective dual imaging for treatment monitoring.
• In vivo studies showed substantial tumor tissue damage and no recurrence after 808-nm laser irradiation.
• The nanocomposite exhibited strong fluorescence/PAI contrast, aiding malignancy detection and inducing cancer cell apoptosis.

Conclusions:

• The anti-EGFR-MPB nanocomposite is effective for in vitro and in vivo photoacoustic image-guided PTT and PDT.
• Integrated targeted dual image-guided phototherapy enhances precision and efficacy in cancer treatment.
• Optimal treatment involved 250 μg/ml nanocomposite with 1.0 W/cm² 808-nm laser for 7 min for triple-negative breast cancer.