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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Related Experiment Video

Updated: May 5, 2026

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
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Recent advances in aptamer discovery, modification and improving performance.

Arezoo Fallah1, Abbas Ali Imani Fooladi2, Seyed Asghar Havaei3

  • 1Department of Bacteriology and Virology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Biochemistry and Biophysics Reports
|November 11, 2024
PubMed
Summary

Aptamers, which are nucleic acids like RNA and ssDNA, offer advantages over antibodies for targeted delivery. This review highlights advanced methods for discovering and modifying aptamers to enhance their affinity and clinical applications.

Keywords:
AptamerAptamer modificationsPost-SELEX optimization

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Area of Science:

  • Biotechnology
  • Molecular Biology
  • Biochemistry

Background:

  • Aptamers are nucleic acid molecules (RNA and ssDNA) that bind targets like antibodies.
  • They offer benefits such as stability, low immunogenicity, and targeted delivery, increasing clinical interest.
  • Chemical modifications can enhance aptamer stability and binding affinity.

Purpose of the Study:

  • To review cutting-edge methodologies for aptamer discovery.
  • To discuss techniques for developing high-affinity aptamer modifications.
  • To highlight the potential of aptamers in various clinical applications.

Main Methods:

  • Review of current literature on aptamer discovery and modification techniques.
  • Analysis of chemical modification strategies for enhancing aptamer performance.
  • Discussion of methods for constructing high-performing aptamers efficiently.

Main Results:

  • Advanced aptamer discovery methods are being developed for efficiency and success.
  • Chemical modifications significantly improve aptamer binding affinity to target proteins.
  • Stable, modified aptamers demonstrate enhanced non-covalent binding capabilities.

Conclusions:

  • Novel aptamer discovery and modification techniques are crucial for clinical translation.
  • High-affinity aptamers offer a promising alternative to antibodies in diagnostics and therapeutics.
  • Efficient development of aptamers requires fewer resources with a high success rate.