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T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

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Related Experiment Video

Updated: Jun 7, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Psoriasis Flare Following Paramyxovirus Infection.

Vito Di Lernia¹, Cristina Bertoli²

¹Dermatology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Psoriasis (Auckland, N.Z.)

|November 11, 2024

Summary

Severe psoriasis flare-ups can be triggered by viral infections like mumps. This case study shows how targeting interleukin-23 (IL-23) with risankizumab effectively treated psoriasis exacerbated by paramyxovirus.

Area of Science:

Immunodermatology
Virology
Clinical Case Study

Background:

Psoriasis is a chronic immune-mediated disease influenced by genetic and environmental factors.

Keywords:

infection paramyxovirus psoriasis

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Infections, particularly streptococcal, are known triggers for psoriasis flares.

The association between viral infections and psoriasis exacerbation is less understood but emerging.