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Updated: Jun 7, 2025

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
New Trends in Treating Cushing's Disease
Odysseas Violetis1, Krystallenia I Alexandraki1
12nd Department of Surgery, Aretaieio Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Abstract:
Rates of recurrence and/or persistence of Cushing's disease after surgical treatment are high. Recently, advances in molecular insights and a better understanding of pathophysiology have enabled the development of potential therapeutic targets that could control adrenocorticotropic hormone (ACTH) and cortisol secretion or even reduce tumour cell proliferation. At the pituitary level, pasireotide is an approved somatostatin receptor ligand, and compounds targeting cell cycle regulation, cell signalling and epigenetics are now under investigation. Levoketoconazole and osilodrostat are novel steroid inhibitors, and relacorilant overcomes the adverse effects of mifepristone. Adrenal ACTH receptor blockage and immunotherapy could also play a role.
Insights
Cushing's disease often recurs after surgery. New therapies targeting hormone secretion and tumor growth, including pituitary and adrenal treatments, offer improved management options for patients.
Area of Science:
- Endocrinology
- Oncology
- Molecular Medicine
Background:
- High recurrence rates of Cushing's disease post-surgery necessitate novel therapeutic strategies.
- Recent molecular insights into Cushing's disease pathophysiology reveal new therapeutic targets.
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