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A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
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Association of Systemic Inflammatory Response Syndrome With Cardiovascular Events After Mitral Transcatheter
Carlo Mannina1,2, Akarsh Sharma1, Andreina Carbone3
1Department of Medicine Icahn School of Medicine at Mount Sinai New York NY.
Journal of the American Heart Association
|November 11, 2024
Summary
Systemic inflammatory response syndrome (SIRS) after mitral transcatheter edge-to-edge repair predicts major cardiovascular events. Patients with SIRS require closer follow-up due to increased risk of severe mitral regurgitation.
Area of Science:
- Cardiology
- Infectious Disease
- Critical Care Medicine
Background:
- Systemic inflammatory response syndrome (SIRS) is linked to adverse outcomes post-cardiovascular procedures.
- Mitral transcatheter edge-to-edge repair (MTEER) is a growing treatment for mitral regurgitation (MR).
- The occurrence and impact of SIRS following MTEER are not well-established.
Purpose of the Study:
- To determine the incidence of SIRS after MTEER.
- To investigate the association between SIRS and major cardiovascular events (MCE).
- To assess the relationship between SIRS and recurrent MR post-MTEER.
Main Methods:
- 158 patients with severe MR undergoing MTEER were analyzed.
- SIRS was defined by leukocytosis and fever within 48 hours post-intervention.
- Neutrophil-lymphocyte ratio (NLR) was used as a baseline inflammation marker.
Main Results:
- 27.9% of patients developed SIRS post-MTEER.
- SIRS was associated with more severe MR at follow-up (79.5% vs. 62.7%).
- SIRS independently predicted major cardiovascular events (HR 2.73; P=0.03) after adjustment.
Conclusions:
- SIRS following MTEER is a significant independent predictor of major cardiovascular events.
- Patients experiencing SIRS post-MTEER require closer monitoring for severe MR.
- These findings highlight the importance of managing inflammation in MTEER patients.
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