Assessment of genetically modified maize DP51291 (application GMFF-2021-0071)

Area of Science:

• Agricultural Biotechnology
• Genetics
• Food Safety

Background:

• Development of genetically modified (GM) crops for enhanced pest and herbicide resistance is crucial for sustainable agriculture.
• Maize DP51291 was engineered with specific gene cassettes for targeted traits.

Purpose of the Study:

• To assess the food, feed, and environmental safety of genetically modified maize DP51291.
• To compare the safety profile of maize DP51291 against its conventional counterpart and other non-GM varieties.

Main Methods:

• Molecular characterization and bioinformatic analyses of genetic modifications.
• Agronomic, phenotypic, and compositional analyses of maize DP51291 and controls.
• Toxicity and allergenicity assessments of introduced proteins (IPD072Aa, PAT, PMI).

Main Results:

• Molecular and bioinformatic data showed no safety concerns requiring further assessment.
• Compositional analyses revealed minor differences (e.g., phosphorus, manganese, specific fatty acids) that do not pose safety or nutritional risks.
• No evidence of increased toxicity, allergenicity, or adverse effects on human/animal health or the environment was found.

Conclusions:

• Genetically modified maize DP51291 is as safe as conventional maize for consumption and environmental release.
• No post-market monitoring for food/feed or environmental safety is deemed necessary.
• The genetic modification did not alter the overall safety profile of the maize variety.