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Related Concept Videos

Serum Laboratory Studies, Stool Test, Breath Test01:30

Serum Laboratory Studies, Stool Test, Breath Test

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Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
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Related Experiment Video

Updated: Jun 7, 2025

Comparative Analysis of Automatic Fecal Analyzer versus Direct Wet Smear Microscopy for Detecting Parasitic Infections in Stool Samples
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Published on: April 25, 2025

348

Straight-to-Test Pathway in Faecal Immunochemical Testing (FIT)-Negative Patients: A Cost-Effective Approach.

Amal Boulbadaoui1, Muhammad Umair Rashid2, Nandu Nair1

  • 1Colorectal Surgery, University Hospitals of North Midlands (UHNM) NHS Trust, Stoke-on-Trent, GBR.

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Summary
This summary is machine-generated.

The triage-to-test (TTT) pathway for suspected colorectal cancer (CRC) effectively identifies patients needing further investigation. FIT-negative patients rarely have CRC, allowing for reassurance and efficient resource allocation.

Keywords:
cancerdiagnosticsoutpatientpathwaytriage

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Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
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Area of Science:

  • Oncology
  • Gastroenterology
  • Health Services Research

Background:

  • Colorectal cancer (CRC) is a significant health burden in the UK.
  • The National Health Service (NHS) faces diagnostic resource limitations.
  • A Triage-to-Test (TTT) service was developed to improve efficiency in suspected CRC cases.

Purpose of the Study:

  • To evaluate the diagnostic yield of colorectal cancer (CRC) in patients with negative faecal immunochemical testing (FIT) results within a TTT pathway.
  • To assess the effectiveness of risk stratification in managing patients with suspected CRC.
  • To analyze the rate of CRC and non-CRC diagnoses in FIT-negative patients.

Main Methods:

  • Retrospective cohort study of 2,374 symptomatic patients undergoing FIT testing.
  • FIT negativity defined as <9.9 μg/g faeces per NICE guidelines.
  • Patients were risk-stratified based on FIT results and presenting symptoms.

Main Results:

  • 61.5% of patients were FIT-negative (n=1,459).
  • CRC incidence was 0.5% (n=7) in FIT-negative patients versus 9.8% (n=89) in FIT-positive patients.
  • Most FIT-negative patients (32.5%) had no significant pathology.

Conclusions:

  • The FIT-negative TTT pathway allows appropriate investigation of symptomatic patients with red flag symptoms.
  • This pathway provides clinical reassurance and reduces outpatient burden.
  • Efficiently manages diagnostic resources for suspected colorectal cancer.