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Updated: May 12, 2026

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

20.3K

[Thrombotic microangiopathy as a rare complication after lung transplantation]

Mehmet Can Sayar1, Laura Pott2, Stephanie Damm3

  • 1Klinik für Pneumologie, Universitätsspital Zürich, Zürich.

Praxis
|November 12, 2024
PubMed
Abstract

Insights

Atypical hemolytic-uremic syndrome (aHUS) is a rare condition causing organ damage. This case highlights the challenges of diagnosing and managing aHUS in lung transplant recipients.

Area of Science:

  • Nephrology
  • Transplant Medicine
  • Hematology

Background:

  • Thrombotic microangiopathy (TMA) presents with thrombocytopenia, hemolytic anemia, and organ dysfunction due to microthrombi.
  • TMA encompasses thrombotic thrombocytopenic purpura (TTP), Shiga toxin-induced hemolytic uremic syndrome (STEC-HUS), secondary TMA, and atypical hemolytic uremic syndrome (aHUS).

Purpose of the Study:

  • To present a unique case of atypical hemolytic-uremic syndrome (aHUS) in a lung transplant recipient.
  • To illustrate the complexities in diagnosing and managing TMA in the post-transplant setting.

Main Methods:

  • Case report of a 49-year-old lung transplant recipient.
  • Review of diagnostic challenges and management strategies for TMA and aHUS.

Main Results:

  • The patient developed aHUS post-lung transplantation.
  • The case underscores the difficulties in differentiating TMA subtypes and managing aHUS in immunocompromised patients.

Conclusions:

  • Atypical hemolytic-uremic syndrome (aHUS) poses significant diagnostic and therapeutic challenges in lung transplant recipients.
  • Early recognition and tailored management are crucial for improving outcomes in post-transplant TMA.
Keywords:
atypical hemolytic uremic syndromeeculizumablung transplantthrombotic microangiopathy

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