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Updated: Jun 7, 2025
Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
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The Global Prevalence of Iron Deficiency in Collegiate Athletes: A Systematic Review and Meta-Analysis
Christineil Thompson1, Darci Block2, Zhen Wang3
1Division of Pediatric Hematology-Oncology, Mayo Clinic, Rochester, Minnesota, USA.
Abstract:
Athletes are at high risk of iron deficiency even without anemia. In this systematic review and meta-analysis that included 17,519 athletes in 122 references from 23 countries, participating in 62 unique sports over a 41-year timeframe, approximately 53.9% of student-athletes were found to be hypoferritinemic (ferritin concentration below 50 mcg/L) with 23.0% percent showing absolute iron deficiency based on current definitions (ferritin concentration below 20 mcg/L). These findings strongly suggest that changes in clinical practice guidelines are warranted to enable routine screening for iron deficiency among adolescent and collegiate athletes.
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