Related Experiment Video
Updated: Jun 7, 2025
09:06
Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
Published on: February 20, 2019
8.2K
Inflammageing, a targetable pathway for preventing cardiovascular diseases.
Juan Francisco Aranda1, Cristina M Ramírez2, María Mittelbrunn3
1Department of Genetics, Physiology and Microbiology, Faculty of Biology, Complutense University of Madrid, C. de José Antonio Novais, 12, 28040 Madrid, Spain.
Cardiovascular Research
|November 12, 2024
Summary
Inflammaging, chronic inflammation in aging, drives age-related diseases like cardiovascular disease (CVD). Understanding its causes and consequences is key to developing interventions for healthier aging and preventing conditions such as atherosclerosis and heart failure with preserved ejection fraction (HFpEF).
Area of Science:
- Gerontology and Immunology
- Cardiovascular Medicine
- Biomedical Science
Background:
- Inflammaging, persistent chronic inflammation in older adults, is a significant risk factor for major age-related diseases, including cardiovascular diseases (CVDs), metabolic disorders, and cognitive decline.
- Elevated inflammatory mediators, such as cytokines and chemokines, are hallmarks of inflammaging and serve as biomarkers for biological aging.
- Factors contributing to inflammaging include immune system decline, mitochondrial dysfunction, gut dysbiosis, and the accumulation of damage-associated molecular patterns (DAMPs).
Purpose of the Study:
- To review the multifaceted causes and detrimental consequences of inflammaging.
- To specifically examine the role of inflammaging in the pathogenesis of atherosclerosis and heart failure with preserved ejection fraction (HFpEF).
- To explore potential therapeutic strategies for mitigating inflammaging and its impact on cardiovascular disease (CVD) onset and progression.
Main Methods:
- Comprehensive literature review of scientific articles and research studies.
- Analysis of current understanding regarding the biological mechanisms underlying inflammaging.
- Synthesis of evidence linking inflammaging to specific age-related cardiovascular conditions.
Main Results:
- Inflammaging is a complex biological process driven by multiple intrinsic and extrinsic factors.
- A strong correlation exists between inflammaging markers and the development and severity of atherosclerosis and HFpEF.
- Genetic, epigenetic, and lifestyle factors significantly influence the trajectory of inflammaging.
Conclusions:
- Inflammaging is a central mechanism in the aging process, significantly contributing to cardiovascular morbidity and mortality.
- Targeting inflammaging pathways presents a promising therapeutic avenue for preventing and managing age-related cardiovascular diseases.
- Further research into mitigation strategies is crucial for promoting healthy aging and reducing the global burden of chronic diseases.
Related Concept Videos
01:38Inflammation
52.8K
Overview
52.8K
01:28Inflammatory Response
1.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
1.9K
01:21Myocarditis I: Introduction
2
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
2
01:20The JAK-STAT Signaling Pathway
8.7K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.7K
01:26Aging
37
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
37
01:17Ischemic Heart Disease: Overview
1.2K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.2K