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Updated: Jun 7, 2025

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse
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Age-related volume decrease in subcortical gray matter is a part of healthy brain aging in men.

Radmila Peric1,2, Igor Romčević3, Milica Mastilović3

  • 1Department of Radiology, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000, Novi Sad, Serbia. radmila.peric@mf.uns.ac.rs.

Irish Journal of Medical Science
|November 12, 2024
PubMed
Summary
This summary is machine-generated.

Aging significantly reduces subcortical gray matter volume in healthy males, particularly on the right side. These findings aid in differentiating normal aging from neurodegeneration.

Keywords:
AgingMRINeuroimagingSubcortical gray matterVolumetric

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Area of Science:

  • Neuroimaging
  • Gerontology
  • Brain Anatomy

Background:

  • Global population is aging, with individuals over 60 expected to double by 2050.
  • Brain volume naturally declines by 0.2% annually after age 35.
  • Distinguishing normal aging from neurodegeneration is crucial.

Purpose of the Study:

  • Assess the impact of aging on subcortical gray matter in healthy males.
  • Identify potential biomarkers for physiological aging.
  • Understand age-related changes in specific brain structures.

Main Methods:

  • Retrospective analysis of 106 healthy males using brain MRI (3T).
  • Volumetric analysis of subcortical gray matter using VolBrain software.
  • Comparison of gray matter volumes between younger (<35) and older (>35) age groups.

Main Results:

  • No significant difference in total intracranial volume between age groups.
  • Significant reductions (p<0.05) in nucleus accumbens, caudate nucleus, globus pallidus, putamen, thalamus, and ventral diencephalon.
  • Asymmetrical atrophy observed, with greater reduction on the right side in older individuals.

Conclusions:

  • Healthy aging in males involves significant subcortical gray matter volume reduction.
  • Asymmetrical aging patterns are evident, with right-sided structures aging faster.
  • These volumetric changes are key indicators for differentiating healthy aging from neurodegenerative conditions.