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Updated: May 6, 2026

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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
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Migraine and the correlation between stroke: A systematic review and meta-analysis
Weiming Zhao1, Dong Wang2, Yujie Tan1
1Changxing County Traditional Chinese Medicine Hospital of Zhejiang Province, Changxing, China.
Medicine
|November 13, 2024
Summary
Migraine significantly increases stroke risk, particularly in females and young individuals, with or without aura. Further research is needed to validate these findings.
Area of Science:
- Neurology
- Epidemiology
- Public Health
Background:
- Migraine is a common neurological disorder.
- The association between migraine and stroke risk is not fully understood.
- This study investigates the correlation between migraines and stroke incidence.
Purpose of the Study:
- To analyze and evaluate the correlation between migraines and stroke onset.
- To determine if migraines elevate the risk of stroke.
- To explore specific risk factors within migraine populations.
Main Methods:
- A systematic literature search was conducted across major biomedical databases.
- Nine relevant studies were included after applying strict inclusion/exclusion criteria.
- Meta-analysis was performed using Review Manager and Stata software, with quality assessed by the Newcastle-Ottawa Scale (NOS).
Main Results:
- Meta-analysis of 9 studies revealed a statistically significant increased risk of stroke in migraine patients (OR=2.04, 95% CI [1.73, 2.4]).
- Migraine with aura (OR=2.32) and without aura (OR=1.77) both showed increased stroke risk.
- Subgroup analyses indicated a higher risk in female (OR=2.26) and young (OR=2.39) migraine patients.
Conclusions:
- Migraine is reliably associated with an increased risk of stroke.
- Both migraine with and without aura contribute to elevated stroke risk.
- Females and younger individuals with migraines face a disproportionately higher stroke risk, warranting further investigation.
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