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Updated: Jun 7, 2025

Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells
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Extrachromosomal circular DNA and their roles in cancer progression

Siqi Zheng1, Yunong Li1, Lin Wang1

  • 1Department of Pharmacology, School of Pharmacy, China Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation, Liaoning Cancer Immune Peptide Drug Engineering Technology Research Center, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, China Medical University, Shenyang, Liaoning 110122, China.

Genes & Diseases
|November 13, 2024
PubMed

Insights

Extrachromosomal circular DNAs (eccDNAs) drive cancer drug resistance and tumor heterogeneity. Understanding eccDNA biogenesis and function offers new avenues for precision cancer therapy and biomarker discovery.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Extrachromosomal circular DNAs (eccDNAs) are increasingly recognized for their roles in cancer.
  • Their presence is linked to complex regulatory mechanisms influencing cancer progression and treatment resistance.

Purpose of the Study:

  • To review the biogenesis, features, and functions of eccDNA in cancer.
  • To emphasize eccDNA's role in cancer treatment and its potential for therapeutic strategies and biomarker development.

Main Methods:

  • Literature review of existing research on eccDNA in carcinoma.
  • Analysis of eccDNA's impact on oncogene remodeling, splicing, protein interactions, and the tumor microenvironment.

Main Results:

  • eccDNA contributes to drug resistance and increases tumor heterogeneity through oncogene amplification and silencing.
  • eccDNA influences protein interactions, degradation, tumor microenvironment modulation, and cancer stemness.

Conclusions:

  • eccDNA biogenesis and functions are critical in cancer development and treatment.
  • Targeting eccDNA holds promise for novel precision cancer therapies and identifying prognostic biomarkers.
Keywords:
Alternative splicingCancer stem cellExtrachromosomal circle DNAProtein–protein interactionTumor heterogeneityTumor immune microenvironment

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