Related Experiment Video
Updated: Jun 7, 2025
Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
Published on: October 31, 2010
Pediatric Hodgkin Lymphoma in Low- and Middle-Income Countries (LMICs). A Narrative Review
Maria Luisa Moleti1, Anna Maria Testi1, Salma Al-Hadad2
1Department of Translational and Precision Medicine, Sapienza, University of Rome, Rome, Italy.
Insights
Pediatric Hodgkin lymphoma (HL) treatment outcomes are excellent in high-income nations but lag in low- and middle-income countries (LMICs) due to resource scarcity. This review examines HL management and outcomes in LMICs, highlighting critical challenges.
Area of Science:
- Pediatric Oncology
- Hematology
- Global Health
Background:
- Pediatric Hodgkin lymphoma (HL) has a >90% cure rate in high-income countries.
- Outcomes for pediatric HL, especially advanced stages, are significantly poorer in low- and middle-income countries (LMICs).
- Socio-economic factors and limited resources in LMICs impede effective treatment and patient outcomes.
Purpose of the Study:
- To review current literature on pediatric Hodgkin lymphoma management and outcomes in LMICs.
- To identify and discuss critical challenges impacting pediatric HL treatment in resource-limited settings.
- To provide an overview of the current state of pediatric HL care in LMICs.
Main Methods:
- Narrative review of existing literature.
- Synthesis of reported data on pediatric Hodgkin lymphoma management.
- Analysis of factors affecting treatment and outcomes in LMICs.
Main Results:
- Significant disparities exist in pediatric HL treatment success rates between high-income countries and LMICs.
- Limited data is available on pediatric HL management and outcomes specifically within LMICs.
- Resource scarcity and socio-economic challenges are major determinants of poor outcomes in LMICs.
Conclusions:
- Improving pediatric Hodgkin lymphoma outcomes in LMICs requires addressing resource limitations and socio-economic barriers.
- Further research and data collection are crucial to better understand and improve pediatric HL care in LMICs.
- Tailored strategies are needed to enhance treatment efficacy and patient survival for pediatric HL in resource-constrained environments.
Abstract:
Pediatric Hodgkin lymphoma (HL) is a curable disease for more than 90% of children and adolescents in high-income countries. However, similar results cannot be achieved, particularly for advanced disease, in low- and middle-income countries (LMICs), where challenging socio-economic realities and the consequent scarcity of local resources heavily impact the treatment and patients' outcome. Information regarding the management and outcome of pediatric HL in LMICs is still limited. In this narrative review, we summarize the results reported in the literature so far and discuss the critical key points that have emerged from this overview.
Related Concept Videos
02:49Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
01:22Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...