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Nerma Todorovac1, Anne Bruun Krøigård2, Alice Ashouri Christiansen3

  • 1Afdeling for Hjertesygdomme, Sygehus Sønderjylland, Aabenraa.

Ugeskrift for Laeger
|November 13, 2024
PubMed
Summary

Statin-induced immune-mediated necrotising myopathy (IMNM) is a rare condition. This case report details a patient who developed IMNM due to atorvastatin, confirmed by anti-HMGCR antibodies and muscle biopsy.

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Area of Science:

  • Neurology
  • Immunology
  • Pharmacology

Background:

  • Immune-mediated necrotising myopathy (IMNM) is a rare adverse effect of statin therapy.
  • IMNM is a subset of inflammatory myopathies, presenting with muscle pain and elevated creatine kinase (CK).

Observation:

  • A 58-year-old woman developed proximal myopathy and elevated CK levels.
  • The patient was using atorvastatin, a commonly prescribed statin medication.

Findings:

  • Laboratory tests confirmed the presence of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) autoantibodies.
  • Muscle biopsy revealed characteristic myofibre necrosis, confirming the diagnosis of IMNM.

Implications:

  • This case highlights the importance of considering statin-induced IMNM in patients with unexplained myopathy.
  • Identifying anti-HMGCR antibodies is crucial for diagnosing statin-associated IMNM.
  • Early diagnosis and cessation of statin therapy are essential for managing this condition.

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