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Updated: Jun 7, 2025

Growth of Mycobacterium tuberculosis Biofilms
Published on: February 15, 2012
Population-Level Frequency of Fluoroquinolone Resistance by Whole-Genome Sequencing Drug Predictions in Mycobacterium
Elena Ferran1,2, Cathleen Chan1, Noorann Sheikh1
1National Mycobacterial Reference Service, UK Health Security Agency, Birmingham, United Kingdom.
Abstract:
Fluoroquinolones are increasingly important for anti-tuberculosis (TB) treatment. Identifying fluoroquinolone resistance (FR) is essential. Using sequencing data from over 16 000 unselected isolates, this first English survey of FR, found it present in 1.4% overall and 23.9% of multidrug-resistant TB. Routine sequencing allows clinically-relevant resistance surveillance and should be widely adopted.
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