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Mikkel Bundgaard Skotting1, Anders Vedel Holst1, Daniel Kondziella2

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Ugeskrift for Laeger
|November 13, 2024
PubMed
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Posterior reversible encephalopathy syndrome (PRES) is a severe neurological condition with symptoms like headache and seizures. Prompt management focuses on treating the underlying cause, often acute hypertension, to prevent further brain injury.

Area of Science:

  • Neurology
  • Radiology
  • Critical Care Medicine

Background:

  • Posterior reversible encephalopathy syndrome (PRES) is an acute neurological condition.
  • Characterized by headache, encephalopathy, seizures, and visual disturbances.
  • Radiological findings include vasogenic edema in posterior circulation.

Purpose of the Study:

  • To summarize current knowledge on PRES.
  • To review its clinical presentation and radiological findings.
  • To discuss underlying mechanisms and management strategies.

Main Methods:

  • Literature review of existing studies on PRES.
  • Synthesis of information on clinical features, imaging, and etiology.
  • Analysis of current treatment approaches.

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Main Results:

  • PRES presents with distinct neurological symptoms and characteristic imaging findings.
  • Blood-brain barrier dysfunction is implicated in PRES pathophysiology.
  • Acute hypertension is a primary identified cause of PRES.

Conclusions:

  • Understanding PRES is crucial for timely diagnosis and intervention.
  • Management involves addressing the root cause, such as hypertension.
  • Preventing secondary brain injury, like seizures, is a key treatment goal.