Early Postoperative Serum Sirtuin 1 Predicts Postoperative Cognitive Dysfunction in Elderly Patients

Area of Science:

• Cardiology
• Neurology
• Biomarker Discovery

Background:

• Postoperative cognitive dysfunction (POCD) is a frequent complication after cardiac surgery, especially in elderly patients using cardiopulmonary bypass (CPB).
• Sirtuin 1 (SIRT1) is linked to mitigating POCD, but its role as a predictive biomarker is not fully understood.

Purpose of the Study:

• To investigate the potential of Sirtuin 1 (SIRT1) as a predictive biomarker for postoperative cognitive dysfunction (POCD) in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB).

Main Methods:

• Patients undergoing CPB cardiac surgery were assessed for POCD using the Montreal Cognitive Assessment.
• Risk factors for POCD were analyzed, and receiver operating characteristic (ROC) curve analysis evaluated the predictive power of early postoperative serum SIRT1 levels.

Main Results:

• Age, education, CPB duration, aortic occlusion duration, anesthesia duration, and early postoperative serum SIRT1 levels were significantly associated with POCD.
• Lower early postoperative serum SIRT1 levels were observed in patients with POCD.
• SIRT1 demonstrated high sensitivity and specificity as a predictor of POCD. Neuron-specific enolase and S100β levels were elevated in POCD patients and inversely correlated with SIRT1.

Conclusions:

• Early postoperative serum SIRT1 is a sensitive and specific biomarker for predicting POCD in patients undergoing cardiac surgery.
• SIRT1 measurement can aid in anticipating the clinical onset of POCD.