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Defect-insensitive cylindrical surface lattice resonance array and its batch replication for enhanced immunoassay.

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  • 1Key Laboratory of Sensing Technology and Biomedical Instruments of Guangdong Province, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, 518107, Shenzhen, China.

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Summary
This summary is machine-generated.

We developed a novel, defect-tolerant cylindrical surface lattice resonance (SLR) array for enhanced immunoassay sensitivity. This scalable platform offers robust performance and reduced fabrication complexity for biosensing applications.

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Area of Science:

  • Plasmonics
  • Nanotechnology
  • Biosensing

Background:

  • Surface lattice resonances (SLR) enhance plasmonic resonance sensitivity and reduce linewidth (FWHM).
  • Current SLR applications in immunoassays are limited by sensitivity to structural defects and high fabrication costs.

Purpose of the Study:

  • To design a novel three-layer cylindrical SLR array with high tolerance to structural defects.
  • To demonstrate a fabrication method for high-quality, defect-insensitive SLR arrays.
  • To evaluate the performance of these arrays in an immunoassay for detecting immunoglobulin G (IgG).

Main Methods:

  • Fabrication of a three-layer cylindrical SLR array using metal evaporation and nanoimprint lithography.
  • Theoretical simulations to assess defect sensitivity of resonance dips.
  • Experimental characterization of array quality, resonance properties, and spectral sensitivity.

Main Results:

  • The fabricated SLR arrays demonstrated high tolerance to structural defects, confirmed by simulations.
  • Arrays exhibited a low FWHM of 5.1 nm with robust resonance characteristics.
  • The SLR array successfully detected immunoglobulin G (IgG) at concentrations as low as 609 pg/mL.

Conclusions:

  • The novel, defect-insensitive SLR array offers a promising platform for sensitive and scalable immunoassays.
  • The straightforward fabrication method addresses limitations of previous SLR technologies.
  • This advancement facilitates the development of high-performance, cost-effective biosensing platforms.