Related Experiment Video
Updated: Jun 7, 2025

Cochlear Surface Preparation in the Adult Mouse
Published on: November 6, 2019
The role of cochlea extracellular matrix in age-related hearing loss
Weiyi Huang1,2,3, Yiming Zhong1,2,3,4, Kaili Chen1,2,3
1Department of Otolaryngology & Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin 2nd Road, Shanghai, 200025, China.
Abstract:
Age-related hearing loss (ARHL) is a common disease among the elderly. Although its pathogenesis remains unclear by now, it is widely accepted that ARHL is associated with the degenerative alterations within each component of the cochlea. Extracellular matrix (ECM) plays a crucial role in cochlear structure and function, providing not only structural support but also participating in vital physiological processes including the development, differentiation, survival of auditory sensory cells, and sound perception. ECM is implicated in the pathogenesis of various neurodegenerative diseases, with certain ECM proteins or associated molecules emerging as potential therapeutic targets. However, few research were carried out on ECM in the cochlea and ECM associated molecules in ARHL. This review aims to delineate the composition of ECM in the cochlea, the changes of the main ECM structure in the cochlea such as the tectorial membrane (TM), the basilar membrane (BM) and the spiral ligament (SL) during aging, as well as the role of ECM associated molecules in ARHL. We hope that this review will foster further research into ARHL.
Related Concept Videos
The Cochlea
Extracellular Matrix
The Extracellular Matrix
Hair Cells
Anatomy of the Ear
The Effect of Aging on Tissues

