Every Fever Not Merely Due to Antibiotic Deficiency: Chronic Graft-Versus-Host Disease Case Report

This case report presents a 53-year-old female patient with a history of acute lymphoblastic leukemia (ALL) who developed chronic graft-versus-host disease (cGVHD) following an allogeneic bone marrow transplant, leading to significant respiratory distress and notable skin findings, including hyperpigmentation and chronic non-healing ulcers. The patient's clinical course illustrates the diverse manifestations of cGVHD, emphasizing the importance of recognizing that not all febrile episodes in post-transplant patients are attributable solely to infection. A multidisciplinary approach was essential for accurate diagnosis and management, underscoring the need for comprehensive evaluation of symptoms in immunocompromised patients. This case contributes to the understanding of cGVHD's clinical implications and highlights the necessity for ongoing research in its management.