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Related Experiment Video

Updated: Jul 13, 2026

The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse

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Published on: July 25, 2011

Lactylation and Ischemic Stroke: Research Progress and Potential Relationship.

Jingyuan Zhang¹, Feng Lin¹, Yue Xu¹

¹Department of Cerebrovascular Disease, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong Province, China.

Molecular Neurobiology

|November 14, 2024

Summary

Lactylation, a new protein modification, may play a role in ischemic stroke. Further research could lead to new drug development for this condition.

Keywords:

Ischemic stroke Lactylation Metabolism reprogramming Neuroinflammation Post-translational modification

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Area of Science:

Biochemistry
Neuroscience
Pathophysiology

Background:

Ischemic stroke is a major global cause of death and disability.
Understanding stroke pathophysiology is crucial for developing effective treatments.
Lactylation is a newly identified post-translational modification with roles in various biological processes.

Purpose of the Study:

To review the current understanding of protein lactylation in different contexts.
To explore the potential involvement of lactylation in ischemic stroke.
To identify potential mechanisms linking lactylation to stroke pathophysiology and repair.

Main Methods:

Literature review of protein lactylation.
Analysis of existing research on stroke pathophysiology.
Hypothesizing potential roles of lactylation in ischemic stroke based on current evidence.

Main Results:

Protein lactylation is involved in diverse physiological and pathological processes.
A potential link between lactylation and ischemic stroke is proposed.
Neuroinflammation, metabolism, mRNA translation, angiogenesis, and neurogenesis are identified as potential mediating pathways.

Conclusions:

Lactylation may significantly contribute to the pathophysiology and repair mechanisms of ischemic stroke.
This review offers a novel perspective on lactylation in stroke.
Lactylation presents a potential therapeutic target for ischemic stroke drug development.