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Updated: Jun 7, 2025

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Innovations in Acne.

Bruna Galvao de Oliveira Wafae1, John S Barbieri2

  • 1Department of Dermatology, Brigham and Women's Hospital, 41 Avenue Louis Pasteur, 317A, Boston, MA 02115, USA; Department of Dermatology, Harvard Medical School, Boston, MA, USA; Department of Dermatology, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, USA.

Dermatologic Clinics
|November 14, 2024
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Summary
This summary is machine-generated.

This review covers new acne treatments, including topical, systemic, and laser therapies. It highlights emerging drugs like sarecycline and clascoterone, and discusses improving patient experience with existing options.

Keywords:
Acne vulgarisAntibioticsClascoteroneLaserMinocyclineRetinoidsSarecyclineTrifarotene

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Area of Science:

  • Dermatology
  • Medical Science

Background:

  • Acne vulgaris presents significant challenges due to treatment limitations.
  • Current therapies face issues with efficacy, patient adherence, and accessibility.

Purpose of the Study:

  • To provide a comprehensive review of recent advancements in acne management.
  • To explore emerging and established therapeutic options for acne vulgaris.

Main Methods:

  • Literature review of topical, systemic, and procedural acne treatments.
  • Analysis of pivotal trial data for novel therapies.
  • Summary of the clinical pipeline for acne management.

Main Results:

  • Emerging therapies include 1726 nm laser, sarecycline, clascoterone, trifarotene, minocycline foam, and fixed-dose combination topicals.
  • The review details mechanisms of action and clinical roles for these new agents.
  • Opportunities for enhancing patient experience with spironolactone and isotretinoin are identified.

Conclusions:

  • Novel therapeutic agents offer promising advancements in acne treatment.
  • Optimizing patient experience with existing treatments remains crucial.
  • A comprehensive understanding of the evolving acne treatment landscape is essential for clinicians.