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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
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Squamous Cells in Thyroid Cytology and Their Clinical Significance: A Multi-Institutional Study
Brian A Pedro1, Iiris Harjunpää2, Eric Young1
1Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland, USA.
Diagnostic Cytopathology
|November 15, 2024
Summary
Squamous cells in thyroid fine needle aspirations (FNAs) present diagnostic challenges. A multi-institutional review found a broad differential diagnosis, emphasizing clinical context for accurate interpretation of these uncommon thyroid FNA findings.
Area of Science:
- Cytopathology
- Endocrinology
- Oncology
Background:
- Squamous cells are rare in thyroid fine needle aspirations (FNAs), posing diagnostic difficulties.
- This study details a multi-institutional experience with thyroid FNAs containing squamous cells.
Purpose of the Study:
- To analyze the diagnostic spectrum and clinical significance of squamous cells identified in thyroid FNAs.
- To evaluate the concordance of FNA findings with surgical pathology and ancillary studies.
Main Methods:
- A retrospective search of electronic data from three institutions (2001-2023) identified thyroid FNAs with squamous cells.
- Patient demographics, clinical history, and pathological diagnoses were recorded and analyzed.
Main Results:
- 107 cases (103 patients) were identified, with 44.9% malignant (primary or metastatic squamous cell carcinomas) and 25.2% benign (cystic changes).
- Follow-up data showed high concordance (91.7%) between FNA and surgical diagnoses, including various squamous cell carcinomas and anaplastic thyroid carcinoma.
- Ancillary studies confirmed HPV-related squamous cell carcinoma and identified therapeutic targets.
Conclusions:
- Thyroid FNAs with squamous cells have a wide differential diagnosis and variable prognoses.
- Integrating clinical and radiographic findings is essential for accurate interpretation and optimal patient management.
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