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Naproxen-induced pseudoporphyria. A clinical and ultrastructural study.
Archives of Dermatology
|April 1, 1986
Summary
Pseudoporphyria, a skin condition, mimics porphyria cutanea tarda but lacks heme synthesis defects. Symptoms in a patient with pseudoporphyria resolved after discontinuing naproxen.
Area of Science:
- Dermatology
- Biochemistry
Background:
- Pseudoporphyria presents clinically and ultrastructurally similar to porphyria cutanea tarda.
- Unlike porphyria cutanea tarda, pseudoporphyria is not associated with abnormalities in heme synthesis.
Observation:
- A 45-year-old woman presented with blisters on the dorsal aspects of her hands.
- Investigations confirmed a diagnosis of pseudoporphyria.
Findings:
- The patient's pseudoporphyria symptoms showed significant improvement.
- Symptom remission was observed after the discontinuation of naproxen medication.
Implications:
- This case highlights the potential iatrogenic cause of pseudoporphyria.
- Naproxen should be considered as a potential trigger for pseudoporphyria in clinical practice.
- Early identification and withdrawal of the causative agent can lead to symptom resolution.