Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Sclerosing mesenteritis. Response to cyclophosphamide.

R W Bush, S P Hammar, R H Rudolph

Archives of Internal Medicine

|March 1, 1986

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Performance and ergonomic characteristics of expert surgeons using a face-mounted display during virtual reality-simulated laparoscopic surgery: an electromyographically based study.

Surgical endoscopy·2006

Same author

Well-differentiated papillary mesothelioma.

The American journal of surgical pathology·2001

Same author

Malignant mesothelioma from neighborhood exposure to anthophyllite asbestos.

American journal of industrial medicine·2001

Same author

Allogeneic marrow engraftment following whole body irradiation in a patient with leukemia. 1970.

Journal of hematotherapy & stem cell research·2001

Same author

Pulmonary atypical carcinoid: predictors of survival in 106 cases.

Human pathology·2000

Same author

Asbestos in extrapulmonary sites: omentum and mesentery.

Chest·2000

Same journal

Elevated CK-MB With Normal Total Creatine Kinase Levels in Patients Undergoing Maintenance Hemodialysis-Reply.

Archives of internal medicine·2017

Same journal

Occult Carbon Monoxide Poisoning-Reply.

Archives of internal medicine·2017

Same journal

Acquired Immune Deficiency Syndrome-Reply.

Archives of internal medicine·2017

Same journal

Heparin Side Effects-Reply.

Archives of internal medicine·2017

Same journal

Humanizing primary care medicine begins with stress.

Archives of internal medicine·2017

Same journal

Legend omitted and number misrepresented.

Archives of internal medicine·2013

See all related articles

Aggressive sclerosing mesenteritis can be life-threatening. Early immunosuppressive therapy with cyclophosphamide offers a dramatic, lasting improvement for patients, especially when tubuloreticular structures are present.

Area of Science:

Gastroenterology
Pathology
Immunology

Background:

Sclerosing mesenteritis is a rare, potentially aggressive inflammatory condition affecting the mesentery.
Characterized by progressive fibrosis, it can lead to significant morbidity and mortality.
The presence of tubuloreticular structures suggests a potential link to autoimmune processes.

Observation:

Two patients presented with aggressive sclerosing mesenteritis, featuring extensive retroperitoneal disease.
One patient exhibited tubuloreticular structures, an ultrastructural finding linked to autoimmune conditions and cyclophosphamide responsiveness.
Both cases demonstrated a severe, life-threatening clinical course.

Findings:

Aggressive immunosuppressive therapy utilizing cyclophosphamide was initiated in both patients.

Related Experiment Videos

Prompt and dramatic clinical improvement was observed in both cases following cyclophosphamide treatment.

No recurrence of the disease was noted during the follow-up period.

Implications:

Cyclophosphamide is a highly effective treatment for aggressive sclerosing mesenteritis.
Early intervention with cyclophosphamide is recommended, particularly in cases with tubuloreticular structures.
This approach may significantly alter the prognosis of this rare and severe disease.