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Related Experiment Video

Updated: Jun 7, 2025

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

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Published on: November 5, 2019

DEPRESSION AS A PREDICTOR OF OPIOID USE DISORDER IN SICKLE CELL DISEASE PATIENTS.

M U Umar¹, A I Yakubu², A T Bakare²

¹Department of Psychiatry, Aminu Kano Teaching Hospital, Kano, Kano State, Niger.

West African Journal of Medicine

|November 15, 2024

Summary

Major depressive disorder predicts opioid use disorder in sickle cell disease patients in Nigeria. Early depression screening and intervention are crucial for managing sickle cell disease complications.

Keywords:

Major depressive disorder Opioid use disorder Sickle cell disease

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Area of Science:

Medical Research
Psychiatry
Hematology

Background:

Sickle Cell Disease (SCD) is a significant health burden in Africa, particularly Nigeria, with high mortality rates.
Depression is common in SCD patients, exacerbating pain and opioid misuse, negatively impacting quality of life.

Purpose of the Study:

To investigate if major depressive disorder (MDD) predicts opioid use disorder (OUD) in patients with SCD.

Main Methods:

A cross-sectional study was conducted at UDUTH Sokoto using psychometric instruments.
Systematic sampling and data analysis via SPSS v25, employing Chi-square and regression analyses.

Main Results:

Significant associations were found between OUD and lack of insurance, MDD, and pain scores.
Major depressive disorder (MDD) was identified as a significant predictor of opioid use disorder (OUD) (AOR: 0.174, p < 0.001).

Conclusions:

Major depressive disorder is a key predictor of opioid use disorder in sickle cell disease patients.
Routine depression screening and prompt intervention are essential for managing SCD patients.