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Related Experiment Video

Updated: Jun 20, 2026

Angiogenesis in the Ischemic Rat Lung

Angiogenesis in the Ischemic Rat Lung

Published on: February 8, 2013

Streptozotocin-induced morphological changes in rat lungs.

Felicia M Masetla¹, Mia-Jeanne Van Rooy², June C Serem¹

¹Department of Anatomy, Faculty of Health Sciences, University of Pretoria, Arcadia, South Africa.

Ultrastructural Pathology

|November 15, 2024

Summary

Streptozotocin (STZ) induces significant lung damage, including alveolar thickening and mitochondrial injury in pneumocytes. Researchers recommend considering STZ

Keywords:

Streptozotocin lungs, diabetes, rats

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Area of Science:

Pathology
Toxicology
Respiratory Medicine

Background:

Streptozotocin (STZ) is widely used to induce type 2 diabetes (T2D) in animal models.
Limited understanding exists regarding STZ's effects on non-pancreatic tissues, specifically the lungs.

Purpose of the Study:

To investigate the histopathological effects of STZ administration on rat lungs.
To characterize cellular and subcellular changes in lung tissue following STZ treatment.

Main Methods:

Male Sprague-Dawley rats were administered STZ after an 8-week high-fat diet and sucrose water regimen.
Lung tissues were analyzed using light microscopy, transmission electron microscopy (TEM), and confocal laser scanning microscopy.
Expression of myeloperoxidase, neutrophil elastase, and citrullinated histone 3 was quantified.

Main Results:

STZ-treated rats exhibited thickened alveolar septa, narrowed alveoli, and inflammatory infiltrates.
TEM revealed mitochondrial damage in type 2 pneumocytes, including membrane fragmentation and cristae loss.
Confocal microscopy showed significantly increased myeloperoxidase, neutrophil elastase, and citrullinated histone 3 in STZ-treated lungs.

Conclusions:

STZ administration causes substantial lung histopathological damage.
Mitochondrial dysfunction and neutrophil activation are key features of STZ-induced lung injury.
Lung toxicity should be considered in research utilizing STZ for diabetes induction.