Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

287
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
287
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

121
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
121
Drug Biotransformation: Overview01:16

Drug Biotransformation: Overview

2.3K
Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
2.3K
Noncompartmental Analysis: Mean Transit, Absorption and Dissolution Time01:02

Noncompartmental Analysis: Mean Transit, Absorption and Dissolution Time

64
When drugs are administered extravascularly, a comprehensive evaluation through noncompartmental analysis becomes imperative. This analytical approach considers various parameters that play a crucial role in understanding the pharmacokinetics of these drugs.
One of the key parameters is the mean transit time (MTT), which refers to the total duration required for drug molecules to transit through the body. MTT is determined by calculating the ratio of the area under the moment curve to the area...
64
Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

409
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
409
Pharmacokinetic Models: Overview01:20

Pharmacokinetic Models: Overview

592
Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal...
592

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interaction Analysis using the Cambridge Structural Database - rapid access to intermolecular hydrogen-bond frequencies and uses for coformer selection.

Acta crystallographica Section B, Structural science, crystal engineering and materials·2026
Same author

Accelerated drug development using a digital formulator and a self-driving tableting data factory.

Nature communications·2026
Same author

Mn-Promoted Co/TiO<sub>2</sub> Catalysts: Quantitative Analysis of Cobalt Polymorphs and Stacking Faults and Its Effect on Fischer-Tropsch Synthesis Performance.

ACS catalysis·2026
Same author

Enhancing power density and cycle life of NMC811 battery cathodes <i>via</i> combined dense calendering and laser patterning.

Energy & environmental science·2026
Same author

United by chewing: Hunter-Schreger band-like pattern and wavy enamel in a fossil crocodile suggest functional convergence with mammals and dinosaurs.

Proceedings. Biological sciences·2026
Same author

Predicting the ritonavir crisis by revisiting the polymorph landscape with crystal structure prediction and form 4 structure solution.

Communications chemistry·2025
Same journal

The Role of Zn-Hf Site Proximity and Oxygen Vacancies for Methanol Formation Over ZnHfO<sub>x</sub> Catalysts Under CO<sub>2</sub> Hydrogenation Conditions.

Angewandte Chemie (International ed. in English)·2026
Same journal

Breaking the Linear Scaling Relationship: Bioinspired Electronic Coupling in S-Bridged Fe-Fe Dual Sites for Efficient Oxygen Reduction.

Angewandte Chemie (International ed. in English)·2026
Same journal

Programming Bio-Bio Electronic Interfaces for Light-Driven Interspecies Electron Transfer.

Angewandte Chemie (International ed. in English)·2026
Same journal

Self-Cleaning Solar Evaporation Facilitating Water Electrolysis for Hydrogen Generation From Seawater.

Angewandte Chemie (International ed. in English)·2026
Same journal

Sulfur Vacancy-Enriched Cu<sub>4</sub>SnS<sub>4-x</sub> Nanosheets Enable Synergistic Cuproptosis, Photothermoelectric Catalytic and Immunotherapy.

Angewandte Chemie (International ed. in English)·2026
Same journal

Mechanically Interlocked Indigo Photoswitches.

Angewandte Chemie (International ed. in English)·2026
See all related articles

Related Experiment Video

Updated: Jun 7, 2025

Coherent anti-Stokes Raman Scattering CARS Microscopy Visualizes Pharmaceutical Tablets During Dissolution
09:59

Coherent anti-Stokes Raman Scattering CARS Microscopy Visualizes Pharmaceutical Tablets During Dissolution

Published on: July 4, 2014

18.1K

Spatial and Temporal Visualization of Polymorphic Transformations in Pharmaceutical Tablets.

Julia Gasol-Cardona1,2, Martin R Ward1,2, Olof Gutowski3

  • 1Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, G4 0RE, United Kingdom.

Angewandte Chemie (International Ed. in English)
|November 15, 2024
PubMed
Summary
This summary is machine-generated.

X-ray Diffraction Computed Tomography (XRD-CT) non-destructively analyzes pharmaceutical tablets, revealing compression-induced material changes and in situ hydrolysis reactions of glycolide markers over time.

Keywords:
Pharmaceutical tabletX-Ray Diffraction Computed tomographyX-ray Diffractionmicrocrystalline cellulosephase transitionspressure-induced polymorphism

More Related Videos

Rapid Analysis and Exploration of Fluorescence Microscopy Images
11:41

Rapid Analysis and Exploration of Fluorescence Microscopy Images

Published on: March 19, 2014

12.3K
Improved Visualization and Quantitative Analysis of Drug Effects Using Micropatterned Cells
15:41

Improved Visualization and Quantitative Analysis of Drug Effects Using Micropatterned Cells

Published on: December 2, 2010

17.3K

Related Experiment Videos

Last Updated: Jun 7, 2025

Coherent anti-Stokes Raman Scattering CARS Microscopy Visualizes Pharmaceutical Tablets During Dissolution
09:59

Coherent anti-Stokes Raman Scattering CARS Microscopy Visualizes Pharmaceutical Tablets During Dissolution

Published on: July 4, 2014

18.1K
Rapid Analysis and Exploration of Fluorescence Microscopy Images
11:41

Rapid Analysis and Exploration of Fluorescence Microscopy Images

Published on: March 19, 2014

12.3K
Improved Visualization and Quantitative Analysis of Drug Effects Using Micropatterned Cells
15:41

Improved Visualization and Quantitative Analysis of Drug Effects Using Micropatterned Cells

Published on: December 2, 2010

17.3K

Area of Science:

  • Materials Science
  • Pharmaceutical Science
  • Analytical Chemistry

Background:

  • Non-destructive analysis is crucial for pharmaceutical tablet characterization.
  • Understanding material transformations under compression is vital for manufacturing.
  • X-ray Diffraction Computed Tomography (XRD-CT) offers molecular-level insights with spatial resolution.

Purpose of the Study:

  • To apply XRD-CT for analyzing pharmaceutical tablets under varying compression pressures.
  • To investigate pressure-induced transformations of a glycolide marker within tablets.
  • To study the temporal changes, including hydrolysis, of tablet components.

Main Methods:

  • Application of X-ray Diffraction Computed Tomography (XRD-CT) to pharmaceutical tablets.
  • Utilizing a pressure-sensitive glycolide marker to track compression effects.
  • Conducting follow-up analysis after one month to observe in situ reactions.
  • Employing electron diffraction for structural elucidation of hydrolysis products.

Main Results:

  • XRD-CT successfully revealed material changes within tablets without destruction.
  • Pressure-induced transformations of glycolide were pinpointed within the tablet structure.
  • An in situ hydrolysis reaction of glycolide was observed one month post-compression.
  • The structure of the glycolide hydrolysis product was determined using electron diffraction.

Conclusions:

  • XRD-CT is a powerful tool for non-destructive analysis of pharmaceutical tablet manufacturing processes.
  • The study demonstrated the ability to track dynamic material changes and reactions within tablets over time.
  • Understanding these transformations is key to optimizing tablet quality and stability.