[Diffuse gastric carcinoma in the youth: Case report]

Gastric cancer is the 5th most common neoplasm in Mexico with an incidence of 13.6 per 100,000 inhabitants. In those under 35 years of age, it represents the 13th cause of cancer with an incidence of 0.37 per 100,000 inhabitants.

We present the case of a 21-year-old male patient treated at the High Specialty Medical Unit No. 71 of the Instituto Mexicano del Seguro Social in Torreón, Coahuila, Mexico. He started with burning epigastric pain lasting two months, which progressed with nausea, vomiting, hyporexia and weight loss of 10 kg in two months. Helicobacter pylori (+) in antigen in feces. Jaundice was added with a negative viral panel, laboratory tests with a cholestatic pattern. It was not possible to perform endoscopic cholangiopancreatography (ERCP) due to poor stomach compliance, with the presence of an atypical giant ulcer; the biopsy reported a neoplasm suggestive of diffuse adenocarcinoma. He was admitted for evaluation by interventional radiology for bile duct diversion. Immunohistochemistry (IMQ) reported diffuse gastric adenocarcinoma CD 45 (-), CK AE1 / AE3: (+) intense in neoplastic cells, HER 2 NEU (+). Treatment consisted of bile duct diversion, nasojejunal tube nutrition, and palliative treatment. The patient died one month after hospital admission.

The objective is to generate knowledge of the intentional search for the pathology to make timely diagnoses, in addition to reporting the atypical HER 2 NEU (+) presentation.