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Related Concept Videos

Overview of Somatic Sensory Pathways01:29

Overview of Somatic Sensory Pathways

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Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
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Major Somatic Sensory Pathways01:28

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Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
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Related Experiment Video

Updated: Jun 7, 2025

A Web Tool for Generating High Quality Machine-readable Biological Pathways
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SPathDB: a comprehensive database of spatial pathway activity atlas.

Feng Li1, Xinyu Song1, Wenli Fan1

  • 1College of Bioinformatics Science and Technology, Harbin Medical University, No.157 Baojian Road, Harbin 150081, China.

Nucleic Acids Research
|November 15, 2024
PubMed
Summary

SPathDB is a new database that maps pathway activity in spatial transcriptomics data. It helps researchers understand how functional pathways create cell diversity and heterogeneity in tissues.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Systems Biology

Background:

  • Spatial transcriptomics reveals cell diversity and states within tissues.
  • Tissue heterogeneity is driven by regulatory network functional activities.
  • Understanding spatial functional activity is key to complex biological processes.

Purpose of the Study:

  • To introduce SPathDB, a database for dissecting pathway-mediated spatial heterogeneity.
  • To provide insights into functional activity within tissue space.
  • To link pathway functions to spatial heterogeneity.

Main Methods:

  • Manual curation of spatial transcriptomics datasets and biological pathways.
  • Integration of data from public resources.
  • Development of interactive analysis and visualization tools.

Main Results:

  • SPathDB contains data from 84 spatial transcriptome datasets (human and mouse), covering 36 tissues and diseases like cancer.
  • It includes 1,689,868 spatial spots and analyzes 114,998 pathways.
  • Provides tools to analyze pathway activity variability, distribution, intercellular communication, and cell type associations.

Conclusions:

  • SPathDB serves as a foundational resource for spatial transcriptomics research.
  • It aids in identifying functional features driving spatial heterogeneity.
  • Facilitates elucidation of underlying mechanisms of biological spatial organization.