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Estriol in formation of mononuclear cells tolerogenic features

Irina Nekrasova1, Sergei Shirshev1

  • 1Perm Federal Research Center, Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, Perm 614081, Russia.

Journal of Reproductive Immunology
|November 15, 2024
PubMed

Estriol (E3) is one of hormones whose synthesis is mainly associated with pregnancy. The hormone can also regulate immune cells functions. E3 influence on monocyte indoleamine-2,3-dioxygenase (IDO1) activity and Treg and NK cells' markers expression was investigated. LPS and IFN-γ stimulated IDO1 activity was augmented by Е3 independently of the hormone doses. Both Е3 concentrations increased CD4+Foxp3+ lymphocytes percentage. This hormonal effect was mediated by protein kinase A. CD16 expression upon NK cells was reduced as a result of Е3 influence. The data indicated that Е3 is one of the factors which maintained immune tolerance during pregnancy and protected fetus preservation.

Keywords:
EstriolIndoleamine-2,3-dioxygenaseNK cellsRegulatory T cells

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