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Role of Relaxin Signaling in Cancer: A Review
Anupam Kotwal1, Whitney S Goldner2, Robert G Bennett3
1Department of Internal Medicine, Division of Diabetes, Endocrinology, and Metabolism, University of Nebraska Medical Center, Omaha, NE, USA; VA Nebraska-Western Iowa Health Care System, Omaha, NE, USA.
Biochemical Pharmacology
|November 15, 2024
Summary
Relaxin (RLN) and its receptors (RXFP) influence cancer by affecting the tumor microenvironment and signaling pathways. This review explores RLN
Area of Science:
- Endocrinology and Cancer Biology
- Molecular and Cellular Oncology
- Extracellular Matrix and Signaling Pathways
Background:
- Relaxin (RLN) and relaxin family peptides (RXFPs) are implicated in extracellular matrix remodeling, immune modulation, and angiogenesis.
- Emerging evidence suggests a role for RLN signaling in cancer cell pathways.
- Understanding the complex interplay between RLN and cancer is crucial for therapeutic development.
Purpose of the Study:
- To review and synthesize current literature on the role of relaxin (RLN) and its receptors (RXFP) in various cancers.
- To provide insights into the clinical and investigational significance of RLN-receptor interactions in oncology.
- To identify knowledge gaps and future research directions in the field of RLN and cancer.
Main Methods:
- Narrative review of pertinent studies.
- Focus on evaluating the expression and effects of RLN1, RLN2, and RXFP1 in different cancer types.
- Brief discussion of other RLN family peptides and their receptors in cancer.
Main Results:
- RLN signaling impacts tumor-adjacent cells, tumorigenesis, and potentially influences anti-cancer therapy effectiveness.
- RLN expression and detection in serum are observed in various cancer settings.
- Pregnancy-associated protection from mammary tumors highlights a potential protective role of RLN.
Conclusions:
- RLN-receptor interactions play a significant, multifaceted role in cancer biology.
- Further research is warranted to fully elucidate the therapeutic potential of targeting RLN pathways in cancer treatment.
- The review identifies key areas for future investigation into RLN's impact on tumorigenesis and therapy.
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