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Updated: Jun 7, 2025

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
Genetic polymorphism of the CYP11B2 gene in an Iraqi patient with essential hypertension
Israa Mohammed Mahdy1, Hussein A Saheb1, Ahmed M Sultan1
1DEPARTMENT OF PHARMACOLOGY AND THERAPEUTICS, COLLEGE OF MEDICINE, UNIVERSITY OF AL-QADISIYAH, AL-QADISIYAH, IRAQ.
Objective:
Aim: To demonstrate the genetic variant of CYP11B2 Gen rs1799998 and rs4539 and their ef f ect on systolic and diastolic blood pressure in Iraqi patient with essential hypertension in Aldiwania province.
Patients And Methods:
Materials and Methods: This is an observational cross sectional descriptive single centre study for hypertensive patients at Al-Diwaniyah province, Iraq which is diagnosed according to 2020 ISH. All candidate patients were diagnosed and recruited by specialist caregiving physician/ cardiologist. There was a total of 90 participants, 37 males and 53 women. Aldosterone and renine levels in the plasma were determined from blood samples given voluntarily by patients undergoing genetic testing.
Results:
Results: Regarding rs4539 the most frequent allele was T (112, 62%) while the most frequent genotype was TC (54, 60%). Regarding rs1799998 the most frequent allele was G (97, 54%) while the most frequent genotype was AG (49, 54%).
Conclusion:
Conclusions: There was no signif i cant relationship between rs1799998 (A344>G) and rs4539 (T2718C) with systolic and diastolic blood pressure in Iraqi patient with essential hypertension.
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