Carboxymethylcellulose-based aggregation-induced emission antibacterial material for multifunctional applications.

Area of Science:

• Biomaterials Science
• Materials Chemistry
• Nanotechnology

Background:

• Polysaccharides are biocompatible and widely available natural polymers.
• Developing multifunctional materials with advanced properties is crucial for biomedical and sensing applications.
• Aggregation-Induced Emission (AIE) and Room Temperature Phosphorescence (RTP) are desirable optical properties for advanced materials.

Purpose of the Study:

• To synthesize a novel antibacterial material with dual AIE and RTP properties.
• To investigate the antibacterial efficacy and cytotoxicity of the synthesized material.
• To explore the potential applications of the material in chemical sensing and food safety.

Main Methods:

• Synthesis of PLOCMC via carboxymethylcellulose (CMC) and ε-Poly-Lysine (ε-PL).
• Characterization of AIE and RTP properties of PLOCMC.
• Evaluation of antibacterial activity against Gram-positive and Gram-negative bacteria.
• Assessment of cytotoxicity and responsiveness to Fe³⁺ ions and nitrite.

Main Results:

• Successful synthesis of PLOCMC with combined AIE and RTP phenomena.
• PLOCMC demonstrated significant antibacterial activity against a broad spectrum of bacteria.
• The material exhibited low cytotoxicity, indicating good biocompatibility.
• PLOCMC showed specific responsiveness to Fe³⁺ ions and nitrite.

Conclusions:

• PLOCMC is a promising multifunctional antibacterial material with dual optical properties.
• The material's low cytotoxicity and broad-spectrum antibacterial activity highlight its biomedical potential.
• Responsiveness to Fe³⁺ and nitrite suggests applications in food safety and chemical sensing.