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Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Health

Michael A Raddatz1, Yash Pershad2, Alyssa C Parker2

  • 1Division of Cardiology, Department of Medicine, University of California, Los Angeles, 650 Charles E. Young Dr. South, A2-237 CHS, Los Angeles, CA 90095, USA.

Cardiology Clinics
|November 17, 2024
PubMed

Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related phenomenon in which somatic mutations lead to clonal expansion of hematopoietic stem cells without the development of hematologic abnormalities. A growing body of literature demonstrates an association between CHIP and cardiovascular disease. This pathophysiology demonstrates a novel connection between global inflammation and cardiovascular morbidity. While there is limited consensus addressing the cardiovascular care of these patients, risk factor optimization and disease surveillance are advisable. Investigation into possible therapies is ongoing and provides promise for the treatment of inflammation contributing to cardiovascular disease in patients with and without CHIP.

Keywords:
AtherosclerosisCardiovascular geneticsClonal hematopoiesisInflammation

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