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Updated: Jun 7, 2025
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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
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Cardiovascular Risk in Prostate Cancer
Darryl P Leong1, Filipe Cirne2, Jehonathan H Pinthus3
1Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada; Department of Medicine, McMaster University and Hamilton Health Sciences, Hamilton, Canada.
Cardiology Clinics
|November 17, 2024
Summary
Patients with prostate cancer frequently have cardiovascular disease, a leading cause of death. Treatment like androgen deprivation therapy (ADT) may increase cardiovascular risks, necessitating further research and guideline adherence.
Area of Science:
- Oncology
- Cardiology
- Endocrinology
Background:
- Cardiovascular disease (CVD) is highly prevalent in prostate cancer patients and a significant cause of mortality.
- Existing cardiovascular risk factors in this population are often undertreated according to current guidelines.
- Androgen deprivation therapy (ADT), a common prostate cancer treatment, is associated with metabolic changes that may increase CVD risk.
Purpose of the Study:
- To evaluate the relationship between androgen deprivation therapy (ADT) and adverse cardiovascular events in prostate cancer patients.
- To assess the potential incremental cardiovascular risks associated with androgen receptor signaling inhibitors and CYP17A1 inhibitors.
- To examine the comparative cardiovascular risk between gonadotropin-releasing hormone antagonists and agonists.
Main Methods:
- Review of existing literature and clinical data concerning prostate cancer treatments and cardiovascular outcomes.
- Analysis of the impact of ADT on cardiovascular risk factors such as diabetes and hypertension.
- Exploration of the cardiovascular safety profiles of different classes of hormonal therapies, including inhibitors.
Main Results:
- ADT is linked to increased adiposity and risk of diabetes and hypertension, though its direct association with cardiovascular events needs further confirmation.
- Androgen receptor signaling inhibitors and CYP17A1 inhibitors may add to the risks of hypertension and cardiovascular events in patients on ADT.
- Preliminary evidence suggests potentially lower cardiovascular risk with gonadotropin-releasing hormone antagonists compared to agonists, requiring confirmation.
Conclusions:
- Cardiovascular risk management is critical in prostate cancer patients, especially those undergoing ADT.
- Specific hormonal therapies may influence cardiovascular event rates, necessitating careful patient selection and monitoring.
- Further randomized clinical trials are required to confirm the comparative cardiovascular safety of different ADT agents.
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