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Association of matrix metalloproteinases (MMPs) gene polymorphisms with periodontitis: a systematic review

Ruchi Pandey1, Nandini Gupta2, Tripti Jha2

  • 1Department of Periodontology, Manav Rachna Dental College, School of Dental Sciences, MRIIRS, Faridabad, Haryana, India.

GMS Hygiene and Infection Control
|November 18, 2024
PubMed

Insights

This study found a link between a specific gene variation, matrix metalloproteinase-9 (MMP-9) (-1562C/T) single nucleotide polymorphism (SNP), and periodontitis in the Indian population. This genetic marker may aid in early diagnosis and prevention strategies for periodontal disease.

Area of Science:

  • Genetics
  • Periodontology
  • Biochemistry

Background:

  • Matrix metalloproteinases (MMPs) are key enzymes in periodontal disease pathogenesis.
  • Subgingival plaque bacteria induce MMPs, influencing disease progression.
  • Single nucleotide polymorphisms (SNPs) affect MMP secretion and disease risk.

Purpose of the Study:

  • To investigate the association between MMPs and periodontitis in the Indian population.
  • To identify potential genetic markers for early diagnosis and prevention of periodontitis.

Main Methods:

  • Systematic review of Indian studies published between January 2012 and May 2024.
  • Inclusion of seven studies with a total of 1,046 participants.

Main Results:

  • Substantial evidence supports an association between MMP-9 (-1562C/T) and periodontitis.
  • The MMP-9 (-1562C/T) SNP is a significant genetic factor in the Indian population.

Conclusions:

  • The MMP-9 (-1562C/T) SNP is linked to periodontitis in Indians.
  • This genetic association offers potential for early diagnosis and targeted prevention strategies.
Keywords:
IndiaMMPsSNPsaggressive periodontitischronic periodontitismatrix- metalloproteinasesperiodontitissingle nucleotide polymorphisms

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