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Related Concept Videos

Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

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Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
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Cancer Prevention02:59

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Bulimia Nervosa01:30

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Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
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Genetic Predisposition to Benign Prostatic Hyperplasia: Where Do We Stand?

Martin Hennenberg1, Sheng Hu1, Alexander Tamalunas1

  • 1Department of Urology, LMU University Hospital, LMU Munich, Munich, Germany.

European Urology Open Science
|November 18, 2024
PubMed
Summary
This summary is machine-generated.

Genetic factors contribute significantly to benign prostatic hyperplasia (BPH). While numerous genes are implicated, research is ongoing to understand their specific roles and potential therapeutic targets for BPH.

Keywords:
Benign prostatic hyperplasiaCandidate gene studyGenetic predispositionGenome-wide association studyLower urinary tract symptomsVoiding symptoms

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Area of Science:

  • Urology
  • Genetics
  • Pharmacology

Background:

  • Benign prostatic hyperplasia (BPH) has a significant genetic component, estimated to influence 40-70% of cases.
  • Understanding genetic predisposition is crucial for advancing BPH research and treatment strategies.

Purpose of the Study:

  • To conduct a narrative review of genes and genetic variants associated with BPH and voiding symptoms.
  • To summarize findings from candidate gene studies, genome-wide association studies (GWAS), and Mendelian randomization studies.

Main Methods:

  • A comprehensive literature search of PubMed was performed using relevant keywords related to BPH and LUTS genetics.
  • Reviewed studies included candidate gene analyses, GWAS, and Mendelian randomization studies.

Main Results:

  • Candidate gene studies explored variants in vitamin D receptor, steroid metabolism, and inflammation pathways, with some population-specific findings.
  • GWAS and Mendelian randomization studies identified associations between BPH/voiding symptoms and variants in genes related to hormones, transcription factors, and cellular processes.

Conclusions:

  • Current genetic findings for BPH are largely inconclusive, with limited understanding of individual variant contributions.
  • Drug targetability for identified genes is challenging due to potential side effects, low efficacy, and lack of prostate specificity.