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Drug nanocrystals: Surface engineering and its applications in targeted delivery
Phattalapol Lhaglham1,2,3, Luksika Jiramonai1,2, Yaru Jia1,4
1Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China.
Iscience
|November 18, 2024
Summary
Surface engineering of drug nanocrystals enhances solubility and bioavailability. This approach enables targeted drug delivery for improved treatment effectiveness, particularly in cancer therapy.
Area of Science:
- Nanotechnology
- Materials Science
- Pharmaceutical Sciences
Background:
- Drug nanocrystals offer improved dissolution and solubility, addressing hydrophobicity challenges.
- Surface modification stabilizes nanocrystals, enabling versatile drug delivery platforms.
- Functionalized ligands facilitate targeted delivery for precision medicine.
Purpose of the Study:
- To review surface engineering strategies for drug nanocrystals.
- To discuss preparation methods and ligand design for targeted delivery.
- To explore applications in cancer treatment and future directions.
Main Methods:
- Review of current literature on drug nanocrystal preparation.
- Analysis of surface modification techniques and ligand functionalization.
- Discussion of targeted delivery applications, focusing on cancer.
Main Results:
- Surface engineering enhances drug nanocrystal stability and functionality.
- Targeted delivery strategies improve therapeutic efficacy and reduce side effects.
- Applications in cancer treatment show significant promise.
Conclusions:
- Surface-engineered drug nanocrystals are crucial for advanced drug delivery.
- Targeted approaches offer new avenues for treating complex diseases.
- Further research will broaden applications in precision medicine.
