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Published on: March 14, 2015
Mitochondria-targeted NIR fluorescent probe for viscosity detection in the hepatic ischemia-reperfusion injury models
Xihao Wu1, Lei Sun1, Ziyi Liu1
1Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations and Excipients, College of Chemistry & Materials Science, Hebei University, Baoding, 071002, China.
Abstract:
A novel NIR fluorescent probe, Mito-TZW, was constructed for targeting mitochondria, enabling detection of viscosity changes in biological samples. Mito-TZW was applied to fluorescence imaging of viscosity change in hepatic ischemia-reperfusion cell/tissue models. Mito-TZW provides strong theoretical support for the treatment and prevention of related diseases.
